Author

K. Zhapar

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Review Open access 2026

Plant-Derived DPP-4 Inhibitors in Cardiometabolic Diseases: A Critical Evaluation of the Evidence Base and Priorities for Kazakhstan

The increasing prevalence of obesity, type 2 diabetes mellitus, and associated cardiometabolic complications has intensified the challenge of effectively controlling disturbances in carbohydrate metabolism and highlighted the need for new therapeutic targets and approaches. One promising target is the enzyme DPP-4, whi...

K. Zhapar, D. Samatkyzy, D. I. Valishaeva et al. · BULLETIN of the L.N. Gumilyo... · 0 citations

Review Open access Sep 2026

Plant-Derived Dipeptidyl Peptidase-4 Inhibitors in Cardiometabolic Disorders: A Critical Review of Natural Scaffolds and Experimental Evidence

Cardiometabolic disorders, including obesity, insulin resistance and type 2 diabetes mellitus, remain major biomedical problems closely linked to vascular complications. Dipeptidyl peptidase-4 (DPP-4) is a clinically validated therapeutic target because inhibition of this enzyme prolongs the activity of incretin hormon...

K. Zhapar, D. Samatkyzy, Diana Valishayeva et al. · Biomedicines · 0 citations