Author

Kaelan J. Brennan

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Open access Sep 2026

Enhancer Tuning by Sequence-Specific Repressors

It is proposed that SNAI1/2 function as a molecular dimmer switch—modulating nucleosome dynamics to calibrate enhancer output to achieve precise spatiotemporal control of transcript dosage.

Lucia Ichino, Kaelan J. Brennan, Ben Mallory et al. · bioRxiv · 0 citations

Open access Aug 2026

Cooperativity enables widespread role of low-affinity motifs in chromatin accessibility and increases regulatory potential.

Results show that low-affinity motifs can be accurately mapped, shape the properties of developmental enhancers, and likely play a widespread role in fine-tuning enhancers during evolution.

Melanie Weilert, Kaelan J. Brennan, Khyati Dalal et al. · Cell Genomics · 1 citation