CCR2-high monocyte membrane-coated ginger-derived exosome-like nanoparticles attenuate spinal cord injury by inhibiting ferroptosis-mediated neuronal death and neuroinflammation via Nrf2/GPX4 axis activation.
BACKGROUND Ferroptosis and neuroinflammation are critical pathological processes that drive secondary injury and persistent neurological dysfunction following spinal cord injury (SCI). The CCL2/CCR2 axis predominantly recruits CCR2-high monocytes to lesion sites, further exacerbating local neural damage. Ginger-derived...