Author

Kai Gui

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Open access Sep 2026

Inflammation-associated hsa_circ_0054391 regulates epithelial-mesenchymal transition and vasculogenic mimicry in colorectal cancer via the miR-1252-3p/VEGFA/ZEB1 axis

To define the functional role of hsa_circ_0054391 (circ54391) in CRC progression and to evaluate its potential as a serum biomarker. Circ54391 was identified from databases and its expression was validated in CRC tissues, cell lines, and serum from healthy controls ( n = 34), colorectal polyp patients ( n = 3...

Cheng-Ying Xiong, Zhi-Qiang He, Xiao-Xue Liu et al. · Scientific Reports · 0 citations

Open access Jul 2026

A structural accessibility principle for LbuCas13a activation by noncontiguous DNA

It is shown that activation occurs only when overhang positioning creates an accessible protein–DNA interface, and a structural accessibility principle for LbuCas13a activation by noncontiguous DNA is defined.

Wei-Tao Wang, Yu-Han Chen, Ziyun Li et al. · Nucleic Acids Research · 0 citations

Review Open access Aug 2026

Alternative RNA Splicing in Cancer: Molecular Mechanisms, Functional Consequences, Biomarkers and Therapeutic Opportunities

This review integrates the molecular logic of splice-site selection with the cancer-specific mechanisms that perturb it, summarizes representative isoform switches across the hallmarks of cancer, evaluates emerging technologies and clinical biomarkers, and discusses the opportunities and constraints of translating spli...

Quan-You Wu, Kai Gui · Genes · 0 citations