Author

Kai Guo

2 papers indexed here

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Open access Oct 2026

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

ABSTRACT Recent advancements in single‐cell RNA sequencing (scRNA‐seq) have greatly enhanced our ability to dissect cellular heterogeneity. However, unsupervised clustering often struggles to identify transitional or developmental boundary cells, as existing methods rely on highly variable genes without considering exp...

Fang Huang, Da-Yu Hu, Ya-Qi Dai et al. · Advancement of science · 0 citations

Open access Sep 2026

TFAM Dependent Mitochondrial Fitness Limits CD8⁺ T Cell Immunopathology and Sustains Protective Immunity during Viral Pneumonia

During respiratory virus infection, CD8+ T cells kill infected cells and establish antigen-specific memory, but mechanisms regulating these functions remain incompletely understood. Here, we identify mitochondrial transcription factor A (TFAM)-dependent mitochondrial fitness as a regulator of CD8+ T cell function durin...

Z. Navaeiseddighi, Kai Guo, S. Hasan et al. · bioRxiv · 0 citations