NRF2-WNT5A promotes stem cell persistence and radioresistance in esophageal squamous cancer
The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) drives radioresistance in esophageal squamous cell carcinoma (ESCC), thereby compromising therapeutic efficacy; however, the underlying mechanisms remain elusive. Cancer stem cells (CSCs) are recognized to harbor intrinsic radioresistance reg...