Open access
Aug 2026
Mitochondrial RNA as a broad-spectrum DAMP coordinates antiviral and damage-related immune clearance and confers therapeutic potential
The findings establish the mtRNA-MAVS axis as a central, broadly applicable immune surveillance pathway and provide a mechanistic framework for developing therapies that overcome both viral immune evasion and the limitations of current STING-targeted agonists.
Mingfu Tian, Guangli Li, Zelin Chai et al.
· Cell Death & Disease · 0 citations