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Author

Kai Li

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Aug 2026

FSCN1 promotes rheumatoid arthritis progression via inhibiting TRIM38-mediated ubiquitination of IGF2BP1 in fibroblast-like synoviocytes.

OBJECTIVE Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) synovium acquire a unique aggressive phenotype and produce cytokines that perpetuate inflammation and proteases that contribute to cartilage destruction. Actin bundling protein Fascin-1 (FSCN1) is involved in FLS migration and invasion, but its r...

Liangyu Chen, Jun-Feng Wu, Tao Zhou et al. · 0 citations
Aug 2026

TL1A(TNFSF15)-ENO1 axis promotes osteoarthritis by disrupting redox homeostasis via the PI3K/AKT pathway.

OBJECTIVE Osteoarthritis (OA) is characterized by cartilage degeneration, oxidative stress, and chondrocyte senescence. This study investigated whether TL1A promotes OA through ENO1-associated redox, senescence and PI3K-AKT signaling mechanisms. METHOD Human paired OA cartilage, primary chondrocytes, and mouse age-as...

Xiang Gao, Jun-Tan Li, Chang-Yu Yin et al. · 0 citations

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