Author

Kai-Ming Niu

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Aug 2026

Discovery of a Covalent NLRP3 LRR-Domain Probe: Reversing Renal Fibrosis via Immunometabolic Reprogramming in Organoid and Murine Models.

QX-31 serves as a valuable chemical tool, demonstrating that covalent targeting of this conformational regulatory domain is a viable therapeutic strategy for fibrotic diseases.

Wen-Hui Wu, Yao Yao, Kang Liu et al. · Journal of Medicinal Chemist... · 0 citations