P-hydroxybenzoic acid (p-HBA), with wide applications in food preservatives, pesticides, pharmaceuticals, and liquid crystalline polyether, is currently synthesized via the Kolbe-Schmitt reaction using anhydrous phenolate (PhO-) and carbon dioxide (CO2). However, this reaction typically suffers from poor selectivity, a...
Chiral gem-difluorinated indane scaffolds are valuable fluorinated bioisosteres of medicinally important CH2-containing indane frameworks. Herein, a photodriven enantioselective hydrodifluoroalkylation of methyleneindanes with α-bromodifluoroamides catalyzed by a C2-symmetric chiral arylthiol was developed. This protoc...
Jing Wang, Chao-Ren Shen, Guang-Mang Wang et al.· Organic Letters· 0 citations
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