Author

Kai Yang

5 papers indexed here

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Review Open access Sep 2026

Natural Products Modulate Plaque Macrophage Functional Programs in Atherosclerosis

Abstract Atherosclerosis is a chronic inflammatory and immunometabolic disease in which plaque macrophages integrate lipid-derived danger signals, metabolic stress and cell-death cues to shape foam-cell formation, necrotic-core expansion, fibrous-cap integrity and plaque vulnerability. Moving beyond the conventional M1...

Kai Yang, Shi-Yi Tao, Rui-Kang Liu et al. · Drug Design, Development and... · 0 citations

Review Open access Aug 2026

Comparative effectiveness of dietary supplements in dilated cardiomyopathy: a systematic review and network meta-analysis

Dilated cardiomyopathy (DCM) is a major cause of heart failure and cardiovascular mortality, partly due to impaired myocardial energy metabolism. Dietary supplements may offer benefits through improved mitochondrial function and antioxidant effects, and randomized controlled trials (RCTs) suggest they can enhance...

Yi-Ying Liu, Rui-Kang Liu, Jun Li et al. · BMC Cardiovascular Disorders · 0 citations

Open access Aug 2026

High-fat diet-induced gut microbiota functional reprogramming is associated with metabolic inflammation and cardiac remodeling through the gut-heart axis in mice

Background Gut microbiota alterations have been implicated in the progression of metabolic syndrome (MetS), which increases the risk of cardiovascular disease (CVD) and is influenced by lifestyle factors. However, the specific gut microbiota changes and their functional roles in MetS remain incompletely understood. Aim...

Yan-Kun Feng, Kai Yang, Zhuan Qu et al. · Frontiers in Immunology · 0 citations

Sep 2026

Zhiling Jiangya decoction treats hypertension in rats: An integrative study of network pharmacology, immune infiltration, molecular simulation, and 16S rDNA sequencing.

OBJECTIVE This study integrated network pharmacology, immune infiltration analysis, molecular docking, molecular dynamics simulation, ADMET prediction, 16S rDNA sequencing, and rat experiments to elucidate the potential mechanisms underlying the antihypertensive effects of Zhiling Jiangya Decoction (ZLJYD). METHODS A...

Jia-Qi Meng, Chen-Lu Yuan, Ao-Ran Cheng et al. · Computational biology and ch... · 0 citations

Open access Aug 2026

The metabolic-inflammatory axis in chronic heart failure: integrating the NLR and TyG index for recent-onset atrial fibrillation prediction via machine learning and mediation analysis

Introduction Recent-onset atrial fibrillation (AF) is a common complication of chronic heart failure (CHF), potentially involving both inflammatory and metabolic dysregulation. This study aimed to develop and externally validate an interpretable machine learning (ML) model for predicting recent-onset AF in patients wit...

Chenglong Yao, Xinmei Liu, Runjia Liu et al. · Frontiers in Endocrinology · 0 citations