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#artificial intelligence Preprint Oct 2026

Few Bits, One Law: Toward W2A4KV2

Extreme low-bit LLM compression is most challenging when weights, activations, and KV caches are quantized together: their distributions differ, and quantization errors interact throughout the network. We introduce CanonQ, a unified quantization-aware training framework that addresses these challenges by separating sou...

Kai Yi, Tarek Elgamal, Sruthikesh Surineni et al. · 0 citations
Open access Sep 2026

De novo design of flexible protein interactions with GuideFlip

De novo design of protein binders requires a target structure. However, for flexible targets, such as intrinsically disordered proteins, this structure does not exist until the binder has stabilized the interaction. Such targets are therefore difficult for methods that separate structure generation from sequence design...

Kai Yi, Qing-Chao Chen, Dong-Qi Zhang et al. · 0 citations

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