Author

Kai Yin

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Review Open access Sep 2026

Cellular crosstalk of fibroblast–myofibroblast transition in intestinal homeostasis and disease

Fibroblasts are central components of the intestinal microenvironment and can acquire a myofibroblast phenotype through fibroblast-to-myofibroblast transition (FMT), a process linked to increased tissue mechanosensitivity and active extracellular matrix (ECM) remodeling. In this way, FMT participates in normal intestin...

Hao-Dong Yuan, Lin Zhao, Pei-Qi Xu et al. · Biomarker Research · 0 citations

Aug 2026

Itaconate reduces LPS/GaIN-induced hepatocyte necroptosis by inhibiting ROS-PAD4-mediated extracellular traps of macrophages.

Acute liver failure (ALF) is a critical syndrome characterized by massive hepatocyte death, yet the role of macrophage extracellular traps (METs) in its pathogenesis remains poorly defined. This study investigated the effect and mechanism of the immunometabolite itaconate on MET formation and hepatocyte necroptosis in...

Pei Zhou, Gaochun Xiao, Jun Li et al. · International Immunopharmaco... · 0 citations