Author

Kai Zhang

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Open access Jul 2026

Leishmanial GP63 acts as a protease for the small pore forming toxin aerolysin

The L. major virulence factor lipophosphoglycan defends against pore-forming toxins made by bacterial competitors, while the GP63 metalloproteinase activates pro-aerolysin like furin to protect L. major from aerolysin cytotoxicity.

Chaitanya S. Haram, Sebastián Salinas, Salma Waheed Sheikh et al. · bioRxiv · 0 citations