Open access
Oct 2026
MAMDC2 drives microglia-mediated neuroinflammation via CAND1-dependent IκBα ubiquitination and is targetable by Artemvulactone E.
Sustained microglial activation is a common feature of many neurological disorders, yet the upstream molecular amplifiers that sustain this process remain poorly defined. Our earlier work identified MAM domain-containing 2 (MAMDC2) as an immune regulator enriched in microglia with an established role in antiviral immun...
Tao Liu, Feng Gao, Yi-Liang Wang et al.
· Pharmacological Research · 0 citations