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Author

Kaitlyn C M Grando

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2 papers indexed here

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Open access Oct 2026

A Novel Biofilm Amyloid Ligand for Caspase-11 Drives Hyperactivation in Dendritic Cells

Bacterial biofilms drive persistent infection and chronic inflammation, yet host sensing of biofilm-derived ligands remains poorly understood. Here we identify curli amyloid, an integral component of Enterobacteriaceae biofilms, as a novel activator of the non-canonical inflammasome in human and mouse dendritic cells (...

Shrutika Mintri, Guang-Nan Hu, A. Mathur et al. · 0 citations
Jul 2026

Pro-Inflammatory Response of Human Monocyte-Derived Dendritic Cells to Bacterial Biofilms 2310119

Exposure to biofilms strongly activated hu-moDCs, inducing upregulation of surface expression of MHC and costimulatory molecules and secretion of pro-inflammatory cytokines and chemokines in a dose-dependent manner, therefore irrespective of the presence of LPS.

L. Whiteman, Guang-Nan Hu, Emily Lowry et al. · 0 citations

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