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Kaitlyn J. Partridge

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Review Open access Sep 2026

The Role of the Mammalian Target of Rapamycin in Microglial Phenotypic Polarization

Highlights What are the main findings? mTOR signaling regulates microglial phenotypic plasticity by coordinating many cellular processes including metabolic reprogramming, inflammatory mediator production, and cytoskeletal remodeling. mTORC1 generally amplifies pro-inflammatory microglial responses, whereas mTORC2 appe...

Kaitlyn J. Partridge, Allison D. Ebert · 0 citations

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