Sep 2026
Transient Expression of an IL-1Ra−Fc Fusion Cytokine in Tobacco Species for Improved Anti-inflammatory Therapeutic Potential
The interleukin-1 receptor antagonist (IL-1Ra) is a key anti-inflammatory cytokine that inhibits interleukin-1 signaling by competitively binding to IL-1 receptors. However, recombinant IL-1Ra, currently produced in Escherichia coli, exhibits limited pharmacokinetics and requires frequent administration due to its sh...
Anith Kumar Rajendran, Vaishnavi Ashokkumar, T. Krishnaraj et al.
· ACS Synthetic Biology · 0 citations