T-2 toxin, a type A trichothecene mycotoxin produced by Fusarium species, is recognized as one of the most potent contaminants of cereals and cereal-based products worldwide. Despite decades of investigation, its toxicological profile continues to expand as new mechanistic insights emerge from molecular biology, omics...
K. Jurowski, Adrian Frydrych, E. Nepovimova et al.· Archives of Toxicology· 0 citations
The global rise in life expectancy has led to an increasing prevalence of age-related diseases, including neurodegenerative disorders, cancer, type 2 diabetes mellitus, and cardiovascular conditions, placing substantial societal and economic burdens on healthcare systems worldwide. A key mechanism underlying both aging...
Lukas Fresser, Zofia Chrienova, Jan Gebrt et al.· Frontiers in Pharmacology· 0 citations
It is reported that T‑2 toxin remodels APP and Tau homeostasis, featuring an early decrease in full‑length APP and a delayed, sustained increase in Tau phosphorylation and total Tau, accompanied by dynamic cytokine release.
Tong Nie, Junya Li, Shiqing Tan et al.· Neurotoxicology· 0 citations
This review critically evaluates the evidence base for AI-based toxicity prediction, assesses current challenges and considers the trajectory toward next-generation risk assessment, which requires adherence to the TREAT validation principles and sustained regulatory engagement.
Kamil Kuča, Siddhi Otari, Namrata Singh et al.· Archives of Toxicology· 0 citations
Several promising epidemiological trials linked high dietary intake of vitamins C and E to a reduced risk of Parkinson’s disease, and plant-derived antioxidants such as polyphenols were explored for their ability to combat neuroinflammation and reduce cognitive decline.
K. Jomová, S. Alomar, Richard Valko et al.· Archives of Toxicology· 0 citations
Fruits such as mango (Mangifera indica), apple (Malus × domestica ), tomato (Solanum lycopersicum), and strawberry (Fragaria × ananassa), are consumed worldwide and fall under a highly economical category of crops. In contrast, the postharvest management against fungal infections particularly remains a challenge for ma...
H. Kumar, Kamil Kuča, Nidhi Sethi et al.· Beni-Suef University Journal...· 0 citations
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