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Kamil Kuča

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Review Open access Oct 2026

T-2 toxin toxicity: what do we currently know about the most toxic trichothecene mycotoxin?

T-2 toxin, a type A trichothecene mycotoxin produced by Fusarium species, is recognized as one of the most potent contaminants of cereals and cereal-based products worldwide. Despite decades of investigation, its toxicological profile continues to expand as new mechanistic insights emerge from molecular biology, omics...

K. Jurowski, Adrian Frydrych, E. Nepovimova et al. · 0 citations
Review Open access Oct 2026

Silencing without clearing: pharmacological modulation of the SASP in aging and disease

The global rise in life expectancy has led to an increasing prevalence of age-related diseases, including neurodegenerative disorders, cancer, type 2 diabetes mellitus, and cardiovascular conditions, placing substantial societal and economic burdens on healthcare systems worldwide. A key mechanism underlying both aging...

Lukas Fresser, Zofia Chrienova, Jan Gebrt et al. · 0 citations
Sep 2026

T-2 Toxin Disrupts Alzheimer's-relevant App/Tau Homeostasis via Circadian-p53-Senescence Crosstalk: Evidence from Human Neuroblastoma Cells.

It is reported that T‑2 toxin remodels APP and Tau homeostasis, featuring an early decrease in full‑length APP and a delayed, sustained increase in Tau phosphorylation and total Tau, accompanied by dynamic cytokine release.

Tong Nie, Junya Li, Shiqing Tan et al. · 0 citations
Review Sep 2026

Artificial intelligence in toxicology: current advances, challenges and future directions

This review critically evaluates the evidence base for AI-based toxicity prediction, assesses current challenges and considers the trajectory toward next-generation risk assessment, which requires adherence to the TREAT validation principles and sustained regulatory engagement.

Kamil Kuča, Siddhi Otari, Namrata Singh et al. · 0 citations
Review Open access Aug 2026

Oxidative stress and inflammation in neurodegenerative disorders

Several promising epidemiological trials linked high dietary intake of vitamins C and E to a reduced risk of Parkinson’s disease, and plant-derived antioxidants such as polyphenols were explored for their ability to combat neuroinflammation and reduce cognitive decline.

K. Jomová, S. Alomar, Richard Valko et al. · 0 citations
Review Open access Aug 2026

Postharvest management of fungal pathogens of selected fruits: role of plant extracts, essential oils, edible films/coatings, and green nanoparticles

Fruits such as mango (Mangifera indica), apple (Malus × domestica ), tomato (Solanum lycopersicum), and strawberry (Fragaria × ananassa), are consumed worldwide and fall under a highly economical category of crops. In contrast, the postharvest management against fungal infections particularly remains a challenge for ma...

H. Kumar, Kamil Kuča, Nidhi Sethi et al. · 0 citations

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