Kan-Chih Chen

Association of the major depressive disorder-associated locus rs12415800 with bipolar disorder in a Taiwan Biobank–NHIRD linked cohort

Background Genome-wide association studies in East Asian populations have identified the gene variant, rs12415800, of the Sirtuin 1 gene (SIRT1) as a major depressive disorder (MDD) risk locus with the A allele conferring increased risk. Accumulating evidence suggests that SIRT1-related genetic effects extend beyond MD...