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Review Open access Jul 2026

Epigenetic Mechanisms in Sepsis-Induced Cardiomyopathy: From Pathophysiology to Therapeutic Targets

Sepsis-induced cardiomyopathy (SICM) is a frequent and clinically important complication of sepsis, characterized by acute and often reversible myocardial dysfunction and associated with poor outcomes in critically ill patients. Despite growing recognition of its clinical significance, effective mechanism-based therapi...

Chen Jiang, Zhan-Fei Li, Xi-Jie Dong et al. · 0 citations
Review Open access Aug 2026

The Neuroimmune Axis in Sepsis: From Pathophysiological Circuits to Precision Neuromodulation

Abstract Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response, is characterized by a dynamic progression from hyperinflammation to immunosuppression. Its persistently high mortality underscores the limitations of therapies focused solely on immune homeostasis. This review advocates a para...

Chuntao Wang, Xiaojiang Huang, Chaoyao Hou et al. · 0 citations

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