Aug 2026
Rapamycin-sensitive mTORC1 signaling in the medial prefrontal cortex contributes to the antidepressant-like behavioral effects of shikimic acid in mice.
These findings suggest that SA exerts antidepressant-like effects via rapamycin-sensitive mTORC1-dependent mechanisms within the mPFC, and support SA as a candidate compound targeting mPFC mTORC1-related signaling for novel rapid-acting antidepressants.
Satoshi Deyama, Kana Ito-Shintai, Rinako Sugie et al.
· Life Science · 0 citations