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Open access Aug 2026

A unified framework for local-ancestry-aware genetic association analysis across biobanks

Biobanks increasingly include individuals with admixed genomes, yet conventional genome-wide association study frameworks either exclude participants who cannot be confidently assigned to a discrete ancestry group or ignore ancestry-specific effects. We present FELIX, a scalable framework for local-ancestry-aware genet...

L. Hu, T. Tan, K. Yuan et al. · 0 citations
Open access Sep 2026

All of Us diversity and scale yield context-dependent improvements in polygenic prediction

Leveraging multiancestry and multi-biobank data from the All of Us Research Program and the UK Biobank improves polygenic prediction models for complex traits and diseases, especially for under-represented populations.

K. Tsuo, Zhuo-Zheng Shi, Tian Ge et al. · 0 citations

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