Sep 2026
A bioactive hydrogel regulates chondrocyte fate with hypoxia-mimetic chondrogenic induction and vascular invasion suppression for full-thickness cartilage repair.
Chondrogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is always compromised by hypertrophic maturation, rendering long-term phenotype maintenance a key challenge. While hypoxia drives chondrogenic commitment, sustained hypoxic stimulation within the injured joint paradoxically accelerates hypertrop...
Jia-Hui Liang, Hui-Chun Yan, Xue-Miao Liu et al.
· Biomaterials · 0 citations