Review
Jul 2026
White matter abnormalities in Alzheimer's disease: Implications for pathophysiology, diagnosis, and treatment.
A paradigm-shifting perspective is emphasized: WM degeneration acts not merely as a downstream outcome but as a key driver of AD pathogenesis, capable of accelerating protein aggregation, amplifying neuro inflammation, and compromising neural plasticity.
Zhi-Chun Chen, Kang-Yan Yang, Fei-Fei Lin et al.
· Ageing Research Reviews · 0 citations