Karen Davey

A combinatorial pre-mRNP retention factor network couples nuclear speckle architecture to splicing quality control

Cells must prevent incompletely spliced transcripts from entering the cytoplasm, yet how splicing status is recognized and converted into selective nuclear retention remains unclear. Here, we identify a network of RNA-binding proteins that retain pre-mRNPs within nuclear speckles. Proteomic analysis of splicing interme...