Karen S. Alarcón-Morales

The ALS/FTD-linked protein CHCHD10 associates with the TDP-43 C-terminal domain through a CHCH–helix interface

A CHCH–helix interface is defined that couples homo- and heterotypic assembly equilibria and support an asymmetric interface-buffering model in which CHCHD10 can divert TDP-43CTD from self-association while increasing its own availability for recruitment into sedimentable assemblies.