Seed pairing between a small regulatory RNA and target mRNA determines cleavage by a RNase E with a minimal C-terminal scaffold.
Small regulatory RNAs (sRNAs) can specifically bind to their target mRNAs to inhibit their expression, either by promoting degradation or by blocking translation. However, the molecular determinants that select which repression mode an sRNA employs remain poorly understood. To investigate this, we used the model target...