Open access
Sep 2026
The antibiotic NAB815 does not induce SOS response and toxin production in Shiga toxin-producing Escherichia coli at sub-bactericidal concentrations.
It is demonstrated that exposure of reporter or wild type clinical STEC strains to NAB815 neither triggered the SOS response nor increased Stx1 or Stx2 amounts, indicating that NAB815 may mitigate Stx-mediated toxicity without having an off-target effect on Stx phage activation.
L. Consagra, Karla Bosse-Plois, M. Berger et al.
· International Journal of Med... · 0 citations