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Karmen Recer

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Open access Aug 2026

Conserved water molecules shape the pathogenicity of missense variants in human proteins.

It is suggested that disruption of a single CWM can contribute to long-range structural remodeling observed in a disease-associated variant, and incorporated water-mediated interactions into structural models provides a generalizable framework for interpreting human genetic variation and its contribution to disease.

Janez Konc, Karmen Recer, Tanja Kunej et al. · 0 citations

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