Open access
Sep 2026
Integrated in vitro transcription and oligo-dT affinity chromatography enable multi-cycle reagent recycling for mRNA manufacturing
A platform process underpins the manufacturing of RNA-based vaccines and therapeutics. However, it remains constrained by high operational expenditures from costly reagents, inefficient raw-material utilization, and extensive purification. We report an integrated sequential-batch in vitro transcription (IVT)-oligo-dT c...
Adithya Nair, Ji-Xin Qu, Manoj Pohare et al.
· Molecular Therapy: Nucleic A... · 0 citations