Sep 2026
Abstract IA02: Single-cell regulatory network analysis of therapy-associated cell state remodeling to inform combination strategies in osteosarcoma
Intratumor heterogeneity and plasticity contribute to resistance, as coexisting tumor cell states exhibit non-overlapping drug sensitivities and divergent responses to therapy. Combination therapy design thus requires identifying vulnerabilities of treatment-persistent populations and measuring state-specific drug ef...
Jovana Pavisic, Chelsey M. Burke, Dao-Qi You et al.
· Cancer Research · 0 citations