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Author

Katherine J. Robinson

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Open access Sep 2026

PolyQ-expanded ataxin-3 is associated with mitochondrial alterations in Machado–Joseph disease

ABSTRACT Spinocerebellar ataxia type 3, also known as Machado–Joseph disease (MJD), is a fatal neurodegenerative disease caused by an expanded CAG repeat in ataxin-3 (ATXN3). Here, we investigated mitochondrial alterations across complementary MJD models, including transgenic zebrafish, CMVMJD135 mice and primary neuro...

Ignacio Simó, Katherine J. Robinson, Julia Y. Kam et al. · 1 citation

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