Author

Kathleen L. Poston

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Open access Aug 2026

Physiological Signatures Derived from Wrist Accelerometry Improve Detection of Isolated REM Sleep Behavior Disorder

Isolated REM sleep behavior disorder (iRBD) is the strongest prodromal marker of -synucleinopathies, but polysomnography is impractical for population-scale screening and questionnaires lack sufficient specificity. Beyond nocturnal movement, recently published models can derive sleep staging and other physiological sig...

A. Brink-Kjaer, Johanne Niman Abildgaard, N. Lorenzen et al. · medRxiv · 0 citations

Review Open access Sep 2026

Cognition endpoints for Parkinson's disease: A roadmap for developing patient-focused assessment tools to accelerate drug development

Cognitive dysfunction is a prevalent and impactful feature of Parkinson's disease (PD), with substantial heterogeneity in onset, severity, and progression, and a high lifetime risk of dementia. Despite its clinical importance, effective treatments and fit-for-purpose outcome measures remain limited. This article report...

Chris J. Edgar, Kathleen L. Poston, Cheryl D. Coon et al. · Journal of Parkinson's Disea... · 0 citations