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Author

Kathy K. Niakan

2 papers indexed here

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Open access Oct 2026

XIST drives X-chromosome inactivation and safeguards female extraembryonic cells in humans

X-chromosome inactivation (XCI) is essential for extraembryonic tissue growth and embryo development in mice. However, species-specific differences in its timing and regulation have left its role in human development unclear. Here, we show that the in vitro differentiation of naive human pluripotent stem cells to troph...

Amitesh Panda, L. Carrillo, B. Balaton et al. · 1 citation
Open access Oct 2026

Endogenous retrovirus control of calbindin is essential for human early embryogenesis

The cis-regulatory potential of human endogenous retroviruses (HERVs) that have accumulated in our genome affects diverse host processes, including embryonic development and malignancy, where HERV epigenetic control is reduced. Non–small cell lung cancer optimal growth requires cancer cell–intrinsic expression of the c...

Judith Pape, A. McCarthy, Eduardo Serna-Morales et al. · 0 citations

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