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Author

Katrina M. Hawley

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Jul 2026

Spatiotemporal and molecular factors determining T cell stemness and differentiation in autoimmune Type 1 Diabetes 2328677

Novel transcriptional regulators and niche-dependent signals that determine autoimmune T cell stemness and differentiation are identified, opening novel therapeutic avenues for the prevention and treatment of T1D and other autoimmune diseases.

S. Miakicheva, Katrina M. Hawley, P. Zumbo et al. · 0 citations
Jul 2026

Decoding the role of CD4 T cells in driving autoimmune type 1 diabetes 2333351

Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease where CD8 T cells eliminate insulin-producing β cells in the pancreatic islets. Yet, MHC class II haplotypes confer the greatest genetic risk for the development of T1D, suggesting a critical role for CD4 T cells. Employing the non-obese diabetic (NOD)...

Ian McBain, P. Zumbo, S. Miakicheva et al. · 0 citations
Open access Jul 2026

A unique epigenetic circuitry defines CD8 T cell stemness shared across chronic diseases 2330201

It is found that TSC in chronic infection harbor a LEF1+ TSC pool sharing the core stemness epigenetic and molecular program observed in autoimmune LEF1+ TSC, discovering LEF1 as the master regulator defining T cell stemness and identify novel targets for therapeutic intervention.

Katrina M. Hawley, S. Miakicheva, P. Zumbo et al. · 0 citations

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