Author

Katrina Mogannam

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Open access Oct 2026

Substrate energetics in non-templated DNA synthesis by terminal deoxynucleotidyl transferase

Abstract DNA polymerases typically use deoxyribonucleoside triphosphates (dNTPs) for DNA synthesis, yet the contribution of the γ-phosphate to catalysis remains unclear. Here, we examine the role of substrate energetics in enzyme-catalyzed polymerization using a fidelity-independent model polymerase, terminal deoxynucl...

Katrina Mogannam, A. Lupták · Nucleic Acids Research · 0 citations