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Kaushik V. Amancherla

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Open access Sep 2026

A tRNA-derived small RNA orchestrates cardioprotection through distinct cell-type-specific mechanisms

Pathological cardiac fibrosis and hypertrophy, key contributors to adverse remodeling that drives heart failure (HF), are not adequately targeted by current therapies. We identified tRNA-Asp-GTC-3′tDR, an ischemia-induced tRNA-derived small RNA (tDR), as an endogenous regulator of both remodeling processes across cardi...

Tian Hao, Jin Li, Kaushik V. Amancherla et al. · 0 citations
Open access Aug 2026

Dynamic cellular programs of human cardiac allograft rejection revealed by spatial transcriptomics

Allograft rejection following solid-organ transplantation is a major cause of graft dysfunction and mortality. Current diagnostic approaches rely on histology, which exhibits wide diagnostic variability and lacks clinically relevant molecular phenotyping. Here we leverage image-based spatial transcriptomics at subcellu...

Kaushik V. Amancherla, A. M. Taravella Oill, Xavier Bledsoe et al. · 1 citation

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