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Author

Kayesha Coley

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Open access Sep 2026

Proteome-wide Mendelian randomisation of lung function to identify potential therapeutic targets for respiratory disease

This work identifies proteins that are potentially therapeutic targets for respiratory disease, and which warrant follow-up for utility and safety, and adds to the literature identifying surfactant protein D as a candidate, yet predicts that integrin subunit alpha V (ITGAV) inhibition could impair some lung function me...

Jing Chen, N. Shrine, Kayesha Coley et al. · 0 citations
Open access Jul 2026

Cross-definition GWAS of IBS in 2.8 million individuals reveals cardiometabolic and triglyceride-linked mechanisms

This study provides the most comprehensive assessment of IBS genetics to date, demonstrating reproducible polygenic inheritance and linking IBS risk to convergent neurogastrointestinal and novel cardiometabolic mechanisms, highlight specific biological pathways and actionable mechanisms and outline translational opport...

Biagio Di Lorenzo, L. Camargo Tavares, Cristian Díaz-Muñoz et al. · 0 citations

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