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Author

Kaylee Grabarkewitz

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Sep 2026

Psi RNA-specific Binding Promotes HIV-1 Gag Conformational Change Critical for Immature Viral Particle Assembly.

The immature HIV-1 virion is assembled by the Gag polyprotein using inositol hexakisphosphate (IP6) as an essential assembly co-factor. Gag binds the genomic RNA Psi packaging signal via the nucleocapsid (NC) domain and associates with the plasma membrane via the matrix (MA) domain. Previous studies revealed that Gag e...

Ye-Hong Qiu, Puja Banerjee, Kaylee Grabarkewitz et al. · 0 citations

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