Author

Kaylene J. Simpson

2 papers indexed here

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Open access Oct 2026

Novel RNA polymerase I and cyclin-dependent kinase combination therapy for the treatment of aggressive acute myeloid leukemia.

Despite advances in therapy, specific subtypes of Acute Myeloid Leukemia (AML) remain largely incurable. The small molecule drug CX-5461 exhibits dual target specificity, acting as a first-in-class ribosome biogenesis inhibitor to induce the nucleolar surveillance pathway (NSP), as well as to poison Topoisomerase IIα (...

Nadine Hein, Perlita Poh, Jason A. Powell et al. · Leukemia · 0 citations

Open access Sep 2026

Cell cycle dependent regulation of mRNA export in response to replication stress

A physical checkpoint at nuclear speckles is uncovered that regulates mRNA export during DNA replication in S-phase of the cell cycle and serves to protect the cell from major sources of genome instability by ensuring that R-loop associated mature mRNA is not exported to the cytoplasm.

Tobias D. Williams, Kirstyn T. Carey, W. Hamilton et al. · bioRxiv · 0 citations