Ke Cai

Acox2 deficiency induces cardiac dysfunction via cross-organ metabolic reprogramming in mice

Secondary cardiomyopathies are a major cause of heart failure (HF) with diverse etiologies and high mortality rates. For example, over 50% of patients with end-stage liver disease develop cardiac dysfunction, clinically termed cirrhotic cardiomyopathy (CCM). While serum metabolites mediating cross-organ communica...