Author

Ke Chen

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Open access Aug 2026

Discovery and Characterization of Inhibitors of Ubiquitin Like Modifier Activating Enzyme 5 (UBA5): Targeting the UFMylation Pathway in Cancer and Neurodegenerative Disease

A robust high-throughput screening assay based on AMP-Glo™ and a library of blood–brain barrier–permeable compounds are developed, identifying five inhibitors spanning three distinct scaffolds with low micromolar potency that establish UBA5 as a tractable enzymatic target and provide first-in-class chemical tools to pr...

Vigyasa Singh, Yuansong Wan, Zhisong Gao et al. · ACS Chemical Biology · 0 citations

Jul 2026

Biochemical characterization and assay development for adenylosuccinate synthetase Rv0357c from Mycobacterium tuberculosis.

The expression, purification, and enzymatic characterization of recombinant Mtb ADSS are reported, providing the first comprehensive biochemical framework for studying Mtb ADSS and establishing a foundation for structure-guided inhibitor discovery targeting purine biosynthesis as a novel antitubercular strategy.

Vigyasa Singh, Ran Zhang, Ke Chen et al. · Biochimica et Biophysica Act... · 0 citations

Open access Aug 2026

A Medicinal Chemistry-Centered Evaluation of AlphaFold 3 and Boltz-2 Across Diverse Binding Modalities

AlphaFold 3 (AF3) and Boltz-2 are state-of-the-art AI-based tools for biomolecular structure prediction, but whether their predictions provide useful guidance for lead optimization, SAR interpretation, and virtual screening remains insufficiently characterized. We benchmarked their performance using newly determined so...

Ke Chen, Zuo-Huang Qi, Omar Lozano Ramos et al. · bioRxiv · 0 citations