Decellularized extracellular matrix (dECM) materials derived from cardiac tissues have emerged as multifunctional biomaterials that recapitulate native microenvironmental cues while serving as controlled-release reservoirs of therapeutic agents and cells for cardiac repair. Recent advances have demonstrated that decellularized cardiac ECM (dcECM) hydrogels and patches can localize the release of angiogenic peptides, growth factors, or genes to promote neovascularization and mitigate adverse remodeling. Simultaneously, dcECM platforms have been applied to improve the survival and engraftment of stem cells, cardiomyocytes (CMs), and cardiac progenitor cells (CPCs) in infarcted myocardium, facilitating paracrine signaling and immune modulation. This review summarizes recent progress in the design and translational development of dcECM-based drug and cell delivery strategies for cardiac repair. We emphasized the interactions between matrix composition, its capacity to protect therapeutic factors and enhance cell retention, and therapeutic release profiles that collectively regulate cardiac tissue repair outcomes and highlighted emerging clinical applications and regulatory challenges for next-generation dcECM-based therapeutics.
Jiazhu Xu, Zining Yang, Yufeng Wen et al.· Journal of Controlled Releas...· 0 citations
Chronic diabetic wounds are characterized by prolonged inflammation, elevated reactive oxygen species (ROS), impaired angiogenesis, and delayed healing, often leading to tissue necrosis and amputation. Conventional wound dressings rarely address oxidative stress, dysregulated inflammation, bacterial infection, and local hyperglycemia simultaneously. Here, we developed a multifunctional nanoplatform consisting of tannic acid (TA)-complexed chitosan-polyethylenimine-phenylboronic acid (CPB-TA) nanoparticles embedded within a thermoresponsive poly(N-isopropylacrylamide-co-acrylic acid) [P(NIPAm-co-AAc)] hydrogel. CPB-TA nanoparticles exhibit dual cfDNA-scavenging and antioxidant activity, sequestering cfDNA through combined cationic binding and polyphenol interactions, and reducing ROS via complementary antioxidant mechanisms, thereby dampening inflammatory signaling and protecting reparative cells. The phenylboronic acid groups reversibly capture glucose through dynamic boronate ester bonds, helping to alleviate local hyperglycemia. The hydrogel matrix is designed to be responsive to body temperature, promoting localized delivery of CPB-TA at the wound site. In vitro, CPB-TA nanoparticles promoted macrophage polarization from M1 to M2, protected endothelial cells from oxidative damage, and exhibited antibacterial activity against Escherichia coli and Staphylococcus aureus. In vivo, topical application of CPB-TA@hydrogel accelerated wound closure, enhanced re-epithelialization, and increased collagen deposition in non-infected and S. aureus-infected diabetic mouse models. This multifunctional, mechanism-targeted strategy provides a rational, disease-relevant approach for treating chronic diabetic wounds.
Yuefei Zhu, Na Yan, Yongqiang Xiao et al.· Small· 0 citations