Ke-Cheng Chen

Species-dependent activities of the PINK1–parkin axis

In vitro studies have established that PTEN-induced putative kinase 1 (PINK1) and parkin are central regulators of mitophagy, and loss-of-function mutations in either gene can cause early-onset Parkinson’s disease (PD). Although various animal models, including mice and pigs with PINK1 or PRKN knockout, have largely fa...