Author

Ke Liu

2 papers indexed here

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Review Open access Sep 2026

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

ABSTRACT Lysosome‐targeting chimeras (LYTACs) have emerged as a strategy for eliminating secreted, extracellular, and plasma‐membrane proteins by redirecting them to the endolysosomal system. By coupling target recognition to receptor‐mediated uptake, LYTACs exploit endogenous trafficking pathways to access disease‐ass...

Ke Liu, Xi-Yan Wang, Xiao-Zhen Liu et al. · Advancement of science · 0 citations

Open access Aug 2026

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

ABSTRACT Targeted degradation of membrane proteins via the lysosomal pathway holds great therapeutic promise, yet existing platforms rely on bulky ligands such as glycopolymers, antibodies, or protein nanocages, which complicate synthesis and limit tissue penetration. Here, we repurpose L‑type amino acid transporter 1...

Li-Quan Zhu, Ke Liu, Hao-Tian Liu et al. · Advancement of science · 1 citation