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Ke-Xin Chen

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Review Aug 2026

Aging at the neurovascular interface: an integrative framework linking cardiovascular and cerebrovascular diseases.

Aging is a fundamental driver of cardiovascular and cerebrovascular comorbidities, yet the mechanisms linking aging to concurrent heart and brain diseases remain incompletely understood. The neurovascular interface (NVI) refers to the structural and functional interface through which neural, vascular, and extracellular...

Ke-Xin Chen, Jun Ma, Yong Peng · 0 citations
Sep 2026

IL-1β-driven SERPINE1 Upregulation is Associated with CAD-ICM-related Cardiomyocyte Remodeling.

INTRODUCTION Coronary artery disease (CAD) may progress to ischemic cardiomyopathy (ICM) and heart failure through maladaptive cardiomyocyte remodeling and myocardial fibrosis. This study aimed to identify key molecular mediators linking inflammatory and fibrotic signaling during this pathological transition. METHODS...

Ke-Xin Chen, Xing-Yu He, Xiang-Ming Ning et al. · 0 citations

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