Open access
Sep 2026
NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication
ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive. CRISPR screen identifies PARP1 as a proviral factor that binds viral NS1. ATAC‑seq reveals IAV drives PARP1‑dependent chromatin remodeling at promoter‑proximal regions (−100 to +300 bp), linking PARP...
Shu-Feng Ma, Chang-Yuan Kang, Xi-Xian Liu et al.
· Advancement of science · 0 citations