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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Ke Zhu

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Preprint Aug 2026

Power and Sample Size Calculations for Hybrid Controlled Trials

Hybrid controlled trials (HCTs) augment randomized controls with external controls (ECs) to address practical challenges in randomized controlled trials (RCTs) and improve statistical power in settings such as rare diseases, oncology, and pediatrics. However, prospective sample-size determination is challenging because...

Ke Zhu, Shu Yang, Xiaofei Wang · 0 citations

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