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Author

Keaton Chien

2 papers indexed here

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Oct 2026

A natural compound derivative targeting HADHA disrupts mitochondrial homeostasis and suppresses renal cell carcinoma.

Metastatic renal cell carcinoma (RCC) remains a lethal malignancy, and therapeutic resistance to current targeted and immune-based therapies highlights the need for new treatment strategies. Here, we identify C18-epi-brasilibactin A (CBA) as a selective inhibitor of RCC. High-throughput screening of a compound library...

Ara Jo, Sanjeevram Dhandapani, Zi-Qin Wang et al. · 0 citations
Open access Aug 2026

RUNX1T1 drives stem-like small-cell neuroendocrine prostate cancer identity

It is found that RUNX1T1 is essential for SCNPC survival, as its knockdown induced apoptotic cell death and the acquisition of PRAD-like identity, including alterations in genes involved in cell-cell adhesion and epithelial cell polarity are found.

Zi-Qin Wang, H. Jung, Changhyeon Hong et al. · 0 citations

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